Quality Polypeptide Powder PT-414(Validamine) (CAS:32780-32-8)
|PHYSICAL STATE||Lyophilized Powder|
|SOLUBILITY||Soluble in water or 1% acetic acid|
|STORAGE||Lyophilized peptides although stable at room temperature for 3 months,|
Should be stored desiccated below -18°C.Upon reconstitution of the peptids
It should be stored at 4°C between 2-21 days and for future use below -18°C.
PT-141, the first in a new class of therapies called melanocortin agonists, works through a mechanism of action involving the central nervous system rather than directly on the vascular system.As a result,it may offer significant safety and efficacy benefits over currently available products, which belong to the class of phosphodiesterase-5 (PDE-5) inhibitors.
PT-141 is nasally administered and is both non-invasive and fast acting.Importantly, PT-141 is not expected to be contraindicated in patients taking nitrates for the treatment of cardiovascular disease.Clinical studies have demonstrated PT-141 to be safe and effective and to improve patient experience.
PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte stimulating hormone.MSH, activates certain melanocortin receptors in the process of exerting its effects.Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido.
Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning.Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.
PT-141 is a potential remedy for the treatment of sexual dysfunction;Specifically, male erectile dysfunction.Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.
PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats.Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs.While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.
|Assay(By HPLC)||95% ~105%||98.9%|
|Appearance||White powder||White powder|
|Solubility||Soluble in water or 10% acetic acid to give a clear, colorless solution||Conforms|
|Amino Acid Composition||±10% of theoretical||Conforms|
|Related Substance(By HPLC)||Total Impurities(%) 3.0% Largest Single Impurity(%) 1.0%||1.1% 0.3%|
|Acetate Content(By HPLC)||15.0%||8.0%|
|Water Content(Karl Fischer)||<8.0%||3.5%|
|Peptide content(N determination)||≥80.0%||87.8%|
|Bacterial Endotoxins||< 5 EU/mg||Conforms|
|Peptide Putity(By HPLC)||≥97% by area integration||98.9%|
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