1. Tadalafil Specifications:
|Description|| White Powder|
|Assay(by TLC)|| 98.0%min||98.60%|
|Melting Point|| 301~303degrees||301.0~302.5degrees|
|Loss On Drying|| 0.5%max||0.13%|
|Specific Rotation|| +69~ +71°||+70.0°|
Tadalafil (Tadalifil citrate), a phosphodiesterase type 5 inhibitor, is used to treat erectile dysfunction (ED) and decreased libido in males. Tadalafil works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function. Tadalafil is much longer lasting. Effects can be felt anywhere between 36-48 hours.
Action: Tadalafil improves erectile function significantly, possibly increased sexual activity, and is very safe.
There are limited side effects associated with its use. The most common side effects are headache, upset stomach, back pain, and muscle aches, and usually subside with in a few hours.
Tadalafil was also found to be significantly higher at the end of the month, due to increased sexual activity.
Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Tadalafil, and under the name Adcirca for the treatment of pulmonary arterial hypertension.
Tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension.
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High pressure liquid chromatography(HPLC)
Loss on drying
Residue on ignition
Assay (on dried basis)
The product conform to USP 32.